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Viagra (Sildenafil citrate), which millions of men take for erectile dysfunction (ED), reduces the effects of hormonal stress on the heart by half, according to a study published online in the journal Circulation. Viagra causes genital blood vessels to expand, which helps in maintaining an erection. Recent research also has pointed to its potential usefulness in treating pulmonary hypertension. Prior to the latest findings by a team of Johns Hopkins researchers, it was thought to have little effect on the heart. Viagra, or sildenafil, blunts the strengthened heart beat caused by chemically induced stress, according to study senior author and cardiologist David Kass, MD, a professor at the Johns Hopkins University School of Medicine and its Heart Institute. It thereby lessens both the excess amount of blood and the force used to pump it to the body. "Sildenafil effectively puts a 'brake' on chemical stimulation of the heart," says Kass. Prevents and Reverses Effects of High BP These findings are believed to be the first confirmation in humans that Viagra has a direct effect on the heart. In earlier research, Kass and his team observed a similar effect in mice; Sildenafil blocked the short-term effects of hormonal stress in the heart. Related studies by the group show that sildenafil also prevents and reverses the long-term effects of chronic high blood pressure on the heart. Sildenafil reversed the negative effects on heart muscle weakened by heart failure and enlargement -- a condition called hypertrophy -- in mouse experiments Kass and his team carried out earlier this year. They reported their results in the journal Nature Medicine. "But we had no firm evidence as to whether or how this therapy might work in the human heart," says Kass. "Our latest research provides firm evidence this drug does indeed have an important impact on the heart." Increased Heartbeat Was Slowed Thirty-five healthy men and women, with an average age of 30 and no previous signs of coronary artery disease, participated in the six-month Johns Hopkins study. Within a three-hour timeframe, each participant received two separate injections of dobutamine (5 micrograms per kilogram for five minutes), a synthetic, adrenaline-like chemical that increases heart rate and pumping strength. Between injections, study participants were assigned randomly to a group that was treated with sildenafil (100 milligrams taken orally) or to a group given a sugar pill placebo. All participants then were given the second dobutamine injection to see what effects sildenafil or placebo had on the heart. Measurements of heart function were made before and after each injection. These included blood pressure readings, electrocardiograms and echocardiograms. Blood samples confirmed relatively equal levels of sildenafil and other enzymes. Each dobutamine injection stimulated heart function, increasing heart rate and the force of each heartbeat used to pump blood throughout the body, results showed. "This stimulation is similar to the way the nervous system normally increases heart function when triggered by emotional or exercise stress, or in diseases such as heart failure," notes Kass. After the first injection of dobutamine, the force of heart contraction increased by 150 percent in both groups. In the placebo group, this increase repeated itself after the second injection. However, in the group treated with sildenafil, the increased heartbeat was slowed by 50 percent, resulting in a smaller increase in blood flow and blood pressure generated by the heart in response to chemical stimulation. Between injections, heart function was not altered in the sildenafil group, demonstrating the absence of adverse side effects on the resting human heart. Stops PDE5A Action "Knowing more about the effects of sildenafil on heart function will allow for safer evaluation of its use as a treatment for heart problems," says Kass. "Our results set the stage for further studies of sildenafil's immediate and long-term effects on the heart and its ability to modify other neurohormonal and stress stimuli, including adrenaline and hypertension," he adds. While the precise biological actions of sildenafil in the heart are not fully understood, the drug is known to work by stopping the action of an enzyme, called phosphodiesterase 5 (PDE5A), Kass explains. This enzyme is involved in the breakdown of a key molecule, cyclic GMP, which helps control stresses and limit overgrowth in the heart. PDE5A is also the biological pathway that sildenafil blocks in the penis to prevent the relaxation of blood vessels and thus maintain erections. Copyright 2005 Daily News Central vimax buy penis enlargement pills vimax penis enlargement tool best penis enlagement surgery penis enlagement forum vimax penis enlargement drug cheap penile enlargement pills pro solution pills review homemade penis enlargment
If you'd like to firm up, strengthen or add volume to your breast, then this might be the most important article on breast enlargement you'll ever read. To date, Breast implants is the most effective breast enlargement method. However, even though it has been around for 40 years and technology had been improving, doctors are still unsure about their long-term side effects. Not surprisingly, many women including myself, who want breast enlargement but fear the scalpel, so we try out many pills, lotions, creams and devices advertised as breast enhancer instead. As a group of impulsive believer … most of us let our insecurity about our bodies get ahead of our reasoning capabilities. Most, if not all of these non-surgical breast enlargement methods are likely to give only flat results. They may seem pretty genuine, providing testimonials from “real people” as well as giving 30 to 90 days money back guarantees, but it is worth remembering, that beauty products – unlike prescription drugs are not regulated and do not need government approval or testing before they are marketed. Let’s Consider The Various Breast Enlargement Methods And Their Claims. Firstly, Breast Enlargement Exercises. Since the breasts are composed mainly of mammary glands and fat, no amount of exercise will change their actual size or shape. At best, like some devices – it may help to develop the underlying muscles (known as pectoralis) that support the breasts. When these muscles are larger and firmer, they push the breasts outwards, giving the illusion of larger breasts. What About Various Miracle Breast Enlargement Pills Or Supplements Or Creams? They are generally herbal in origin – containing different quantities of harmless “plant-estrogen” that are found in some 300 plants like, dong quai, soybean, oat bran, fenugreek, wild yam, saw palmetto and so on. Being herbal, they are also being promoted as natural and safe. Yet, one was recently withdrawn from market, when its makers were first sued in United States, as it contains Kava, a south pacific herb, as one of its critical ingredients – before Kava’s is being known to potentially cause fatty liver. This is a classic example, why we should always insist that all the products we use or consume are tested and proven through long-term studies and research. Is There Any Possible Solution To Natural Breast Enlargement? Before you lose all hope, there is one herb – which belongs to the family guminosae, subfamily Papilionoideae or the soy, bean & pea subfamily, known as Pueraria Mirifica or Kwao Kreu” or “Kwao Kreu Kao” (white Kwao Kao), which are commonly found in the north, the west and the northeast of Thailand at the altitude of 300 to 800 metres above sea level. Woman in the rural communities of Thailand have used this tuberous roots effectively as rejuvenating folk medicine for well over a hundreds years before it become well known and received much attention from Thai and foreign scientist, especially the Japanese. Most of the kwao kreu processed by the Japanese are made into medicines and cosmetics commonly used for improving the skin, hair and firming the breasts. This herb is known to ... - Grow hair, strengthen and darken existing ones - Help improve complexion and remove wrinkles - Improves eyesight - Increase energy and vigor leading to more reflexive body movements - Including breast enhancement. In 1940, in a protected biotechnology laboratory, a group of German scientist successfully isolated the phytoestrogen – Miroestrol from the root of Pueraria Mirifica. But, this herb is mistakenly reported then as Butea Superba. It was later on classified as a new plant called Pueraria Mirifica. After another 60 years, in year 2000, another phytoestrogen – deoxymiroestrol is isolated from the root of Pueraria Mirifica. What Makes Pueraria Mirifica The Best Phytoestrogen? "Miroestrol and Deoxymiroestrol " is very different from other phytoestrogen, as it posses highest estrogenic activity among the known phyto-estrogens due to structural similarity to estradiol, (Estradiol is the main human estrogen which can be found in all women who are at the stage of nursing baby (Lactating); as you may notice that all women who are in this stage, their breast will enlarge and gain firmness for feeding purpose. Miroestrol and Deoxymiroestrol Can Only Be Found In Pueraria Mirifica! But not every Pueraria Mirifica are created equal, they varies from species to species and the growing conditions. There are more than 13 species of Pueraria Mirifica and most of them are called "Pueraria Mirifica” or “Kwao Krua Kao" but this doesn’t mean that they are the same, they may look same in the appearance but they produce different results. The only way to differentiate their difference is to measure the amount of Miroestrol and Deoxymiroestrol contain inside the roots of Pueraria Mirifica. An elaborate and expensive test need to be carry out in specialized laboratory to certify the actual amount of Miroestrol and Deoxymiroestrol found in any specific type of Pueraria Mirifica. And not many company would sent their Pueraria Mirifica for such stringent test. Majority of the Pueraria Mirifica products found in the market are made from roots collected from villagers in the forests. And these villagers will be the ones that do the peeling, grinding, and the drying in their homes. Nobody can assure the sanitation, the quality and the amount of Miroestrol found in these Pueraria Mirifica powder. Many foreign companies who have long settled in Thailand even open small shops to purchase the plant from villagers. 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So, Where’s the Infamous “G-Spot”? The term "G-Spot" was first introduced to the public in the book, "The G Spot and Other Recent Discoveries About Human Sexuality" in the 1980s. It referred to an article from 1950 in the International Journal of Sexology in which gynecologist, Dr. Ernest Grafenberg wrote about erotic sensitivity along the anterior vaginal wall. While many people have read or heard about Grafenberg, few have read his actual words. In reality, Grafenberg only uses the word "spot" twice and he uses it to make the opposite point to the way it has been popularly used. He states "there is no spot in the female body, from which sexual desire could not be aroused. Innumerable erotogenic spots are distributed all over the body, from where sexual satisfaction can be elicited; these are so many that we can almost say that there is no part of the female body which does not give sexual response, the partner has only to find the erotogenic zones." The Grafenberg spot (G-Spot) is said to be a sensitive area just behind the front wall of the vagina, between the back of the pubic bone and the cervix. Beverly Whipple, a certified sex educator and counselor, and John D. Perry, an ordained minister, psychologist, and sexologist, named the G-Spot after gynecologist Ernest Grafenberg (1881-1957). Dr. Grafenberg was the first modern physician to describe the area and argue for its importance in female sexual pleasure. His claim is that when this spot is stimulated during sex through vaginal penetration of some kind (fingers during masturbation, penis or other object partly thrusting into the vagina), some women have an orgasm. This orgasm may include a gush of fluid from the urethra -- sometimes called the “female ejaculation” -- however, many experts do not agree on this. It is not considered urine? Is this real? Many gynecologists and physiologist still argue and the debate will probably continue. There has been a large amount of controversy among sex researchers regarding this theory. For women who have felt this gush of urethral fluid, or for those who have found a new pleasure spot, having a name for it confirms their experience. But remember, not all women are sensitive in this area, so be careful not to set up unrealistic expectations for yourself. Try it out; if it works, great, if it doesn't seem sensitive, try to find the spot(s) that are right for you! And of course, enjoy! vimax free penis enlargement exercise free penis enlagement video com enlargment penile penile pump free penis enargement video penis girth enhancement vimax penis enlargement operation penis enlargment surgery picture pnis enlargement tool penis enlagement pic before and after
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